Abstracts

Following the annual NESTAC spring meeting, all abstracts presented will be uploaded here. In time we plan to give each abstract a unique DOI as a citable reference for CV and research portfolio purposes.
Details of previously presented abstracts are archived below.

NESS & NESTAC Scientific Day 2019

3rd May 2019 – Institute of Transplantation, The Freeman Hospital

North East Surgical Training Academy & North East Surgical Society (NESS) May the 3rd 2019 Institute of Transplantation, The Freeman Hospital   Abstract/Presentation Marking Prof John Dark, Mr C Wilson, Mr Neil Jennings   Provisional Program 12-1pm       Buffet Lunch                 (IOT Level4 Atrium) 1-1.05         Introduction                  IOT Lecture Theatre                  J Moir 1.05           …

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ABSTRACT NUMBER: NESS_1   AUTHORSKathrin Freystaetter1, Jennifer Mehew2, Sophie Tait1, Omer Senbaklavaci1, John Dark1,3 AFFILIATIONS1 Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle Upon Tyne, United Kingdom2 Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom3 Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne, United Kingdom CORRESPONDING AUTHOR CONTACT ten.shn@retteatsyerf.nirhtaKLIAME MAIN ABSTRACT TEXTDonor to…

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ABSTRACT NUMBER: NESS_2   AUTHOR Miss Rebecca Martin AFFILIATIONS Trauma and Orthopaedics, Royal Victoria Infirmary, Newcastle upon Tyne CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.buq@73nitramr MAIN ABSTRACT TEXT Introduction Neck of femur fractures are a common presentation and certain patients can be managed with a total hip replacement. To receive a total hip replacement the pelvic X-rays…

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ABSTRACT NUMBER: NESS_3 AUTHORS Daniel J Lin1,2, James CK Ng2, Lei Huang1, Max Robinson3, James O’Hara2, Janet A Wilson2,4, Andrew L Mellor1 AFFILIATIONS 1. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK 2. ENT Department, Freeman Hospital, Newcastle upon Tyne, UK 3. Centre for Oral Health Research, Newcastle University, Newcastle upon Tyne, UK…

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ABSTRACT NUMBER: NESS_4 AUTHORS Sivesh K Kamarajah, BMedSci MBChB,1, 2 James R Bundred, BMedSci,3 Olivier Saint Marc, MD,4 Long R Jiao, MD FRCS,5 Moh’d Abu Hilal, MD, PhD, FRCS, FACS,6 Derek M Manas, MD FRCS,1 Steven A White, MD, FRCPS FRCS1,2 AFFILIATIONS 1. Department of HPB and Transplant Surgery, The Freeman Hospital, Newcastle upon Tyne,…

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ABSTRACT NUMBER: NESS_5   AUTHORS Samuel Tingle, Nina Jordan, Lucy Bates, Katie Cooke, Emily Thompson, Helen M Arthur, Colin Wilson, Neil Sheerin, Simi Ali CORRESPONDING AUTHOR CONTACT EMAIL moc.liamg@elgnitsemajmaS MAIN ABSTRACT TEXT Background: Chronic allograft dysfunction, underpinned by progressive fibrosis, remains a major hurdle in renal transplantation. There is a growing body of research demonstrating…

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ABSTRACT NUMBER: NESS_6 AIM To evaluate the outcome of a recent change in practice in the management of acute gallstone disease in a district general hospital METHODS Consecutive patients from August 2017 to July 2018 who presented as an emergency with biliary colic, acute calculous cholecystitis (AUGIS 2015 guidelines) or mild acute gallstone pancreatitis (Revised…

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ABSTRACT NUMBER: (NESS _ 07)   AUTHORS The Northern Surgical Trainees Research Association AFFILIATIONS The Northern Surgical Trainees Research Association CORRESPONDING AUTHOR CONTACT EMAIL moc.liamg@nabahsoldaf MAIN ABSTRACT TEXT Introduction Traditional treatment of rectal cancer is major surgical resection. The management of early stages has evolved with increasing emphasis on organ preservation, with a number of…

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ABSTRACT NUMBER: NESS_8   Authors Nandhra.S, Boylan.L, Prentis. J, Nesbitt. C and the Northern Vascular Centre Introduction Anaemia in elective cardio-vascular surgery has been shown to have a detrimental impact on clinical outcomes and survival. Non-elective caseload is high in vascular surgery and the timely revascularisation in critical limb-ischaemia (CLI) significantly contributes towards this workload.…

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ABSTRACT NUMBER: NESS_9   AUTHORS Helen MA Ingoe, William Eardley, Catriona McDaid, Amar Rangan, Catherine Hewitt MAIN ABSTRACT TEXT Surgical fixation of rib fractures (SFRF) is growing in popularity as part of optimising care of patients with rib fractures. There is currently no description of the epidemiology of these injuries at a national level; nor has…

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ABSTRACT NUMBER: NESS_12 AUTHORS Emily R Thompson1, Lucy Bates1, Ibrahim K Ibrahim1, Avinash Sewpaul1, Rodrigo Figueriedo1, Ben Stenberg2, Andrew McNeill2, Georgie Wilkins1, Tom Girdlestone1, Henrique de Lamos, Andrew Mellor, Valerie Roobrouck3, Anthony Ting4, Sarah A Hosgood5, Michael L Nicholson5, Andrew J Fisher1, Simi Ali1, Neil Sheerin1, Colin H Wilson AFFILIATIONS 1 NIHR Blood and Transplant…

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ABSTRACT NUMBER: NESS_13   AUTHORS Antony K Sorial1, Ines MJ Hofer1, Maria Tselepi1, Eleanor Parker1, Sarah J Rice1, David J Deehan2 and John Loughlin1 AFFILIATIONS 1) Institute of Genetic Medicine, Newcastle University, 2) Freeman Hospital, Newcastle Upon Tyne CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.lcn@lairoS.ynoT MAIN ABSTRACT TEXT Introduction Osteoarthritis (OA) is highly polygenic and OA associated…

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ABSTRACT NUMBER: NESTAC_14   AUTHORS Wadah Ali, A Suliman, Stephanie Smith, M Jha AFFILIATIONS James Cook University Hospital CORRESPONDING AUTHOR CONTACT EMAIL ten.shn@ila.hadaW MAIN ABSTRACT TEXT Introduction Abdominal X-rays (AXR) are a routinely requested investigation in the emergency department. There is a common tendency to arrange abdominal x rays in “to complete the work up”…

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ABSTRACT NUMBER: NESTAC_15   AUTHORS Farah Mahmoud Ali, Ali Ghareeb, D Garg, Hans Van der Voet, Madan Jha AFFILIATIONS James Cook University Hospital CORRESPONDING AUTHOR CONTACT EMAIL moc.liamg@akzf.haraf   MAIN ABSTRACT TEXT Introduction Squamous cell carcinoma (SCC) is the commonest variant of the rather uncommon anal malignancy. Certain disease-related factors have been established in determining…

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ABSTRACT NUMBER: NESTAC_01 AUTHORS Umar R1, Gudipati M2 AFFILIATIONS 1Medical Student, Newcastle University, Newcastle Upon Tyne. 2Consultant Obstetrics and Gynaecologist, Sunderland Royal Hospital, Sunderland. CORRESPONDING AUTHOR CONTACT EMAIL ku.shn.tfshc@itapidug.ivadham MAIN ABSTRACT TEXT Background • HMB affects one quarter of women of reproductive age and is one of the most common referrals to secondary care. •…

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ABSTRACT NUMBER: NESTAC_02 AUTHORS Miss Bronwyn Woodburn, Miss Oroog Ali, Miss Imogen Cullen, Mr Ryan Ghita, Mr Alastair Hayes, Mr Duncan Light, Miss Kirsty McVey, Mr Fadlo Shaban, Dr Kondo Chilonga, Mr Liam Horgan AFFILIATIONS • Bronwyn Woodburn and Imogen Cullen: Newcastle University, Newcastle, U.K. • Oroog Ali, Alastair Hayes, Duncan Light, Kirsty McVey, Fadlo…

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ABSTRACT NUMBER: NESTAC_03   AUTHORS A. Bean, A. Read, A. Sharpe, S. Plusa AFFILIATIONS Colorectal Surgical Unit, Royal Victoria Infirmary, Newcastle upon Tyne Newcastle University, Newcastle upon Tyne CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.eltsacwen@1naeb.a MAIN ABSTRACT TEXT Introduction Stoma formation can be necessary to treat severe constipation and incontinence, but failure of stoma acceptance means reversal,…

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ABSTRACT NUMBER: (NESTAC_04) AUTHORS Sherilyn Chew1 David Hamilton2 AFFILIATIONS Faculty of Medical Sciences, Newcastle University1 ENT Department, Freeman Hospital2 CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.eltsacwen@1wehc.S ku.ca.eltsacwen@notlimah.divaD MAIN ABSTRACT TEXT Background The National Institute for Health and Care Excellence (NICE) states that CT thorax is not required in patients with primary T1/T2 laryngeal cancer. Smoking is a…

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ABSTRACT NUMBER: NESTAC_05 AUTHORS Timothy Shun Man Chu1, Chad Chang2, Sahan Rannan-Eliya2 AFFILIATIONS Newcastle University1. Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary2. CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.eltsacwen@1uhC.T MAIN ABSTRACT TEXT Introduction Squamous cell carcinoma (SCC) is the second commonest form of skin cancer. The British Association of Dermatologists (BAD) states that metastatic rate…

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ABSTRACT NUMBER: NESTAC_06   AUTHORS Joseph Battle1, Lucy Bates1,2, Professor Neil Sheerin1,2, Professor John Dark1,2 AFFILIATIONS 1 Newcastle University, 2 Freeman Hospital CORRESPONDING AUTHOR CONTACT EMAIL ku.oc.liamtoh@elttabeoj MAIN ABSTRACT TEXT Introduction Acute Kidney Injury (AKI) is common post-cardiac surgery, with up to 30% of cardiac surgery patients going on to develop an AKI. Currently clinicians…

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ABSTRACT NUMBER: NESTAC_07 AUTHORS Raiyyan Aftab, Dr Rishab Kapoor, Professor Neil Sheerin AFFILIATIONS Institute of Cellular Medicine, Newcastle University Kidney Research UK CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.eltsacwen@batfa.r MAIN ABSTRACT TEXT Background Acute Kidney Injury (AKI) is associated with increased mortality amongst patients. One of the most common causes of AKI is ischaemia which leads to…

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ABSTRACT NUMBER: NESTAC_08   AUTHORS Michaela Paul1, Emily R Thompson1, IK Ibrahim1, Derek M Manas2, Steve A White2, Colin H Wilson1, 2 AFFILIATIONS 1 NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Newcastle University, Newcastle upon Tyne, NE2 4HH 2 Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, NE7 7DN CORRESPONDING AUTHOR…

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ABSTRACT NUMBER: NESTAC_09   AUTHORS Sai SJ Wunnava, Stuart M Robinson, Steven A White, Derek M Manas, Peter Littler CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.eltsacwen@avannuw.j.s.s MAIN ABSTRACT TEXT Introduction Hepatic resection remains the gold-standard in management of colorectal liver metastases however thermal ablation is often utilised as an alternative in patients with small volume oligometastatic disease…

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ABSTRACT NUMBER: NESTAC_10   AUTHORS Andrew Callaway, Mr Andrew Bowey AFFILIATIONS Newcastle University Medical School CORRESPONDING AUTHOR CONTACT EMAIL moc.liamg@59yawallac.werdnA MAIN ABSTRACT TEXT Background Surgical site infection is a significant and costly complication in spinal surgery. The Royal Victoria Infirmary spinal surgery department uses root cause analysis in each incidence of surgical site infection. Used…

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ABSTRACT NUMBER: (NESTAC_11)   AUTHORS Shivam Rana AFFILIATIONS Newcastle University (under supervision of Professor Amar Rangan, Orthopaedics Surgeon, James Cook University Hospital) CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.eltsacwen@4anar.s MAIN ABSTRACT TEXT Background Good record keeping is of paramount importance for patient safety and for medico-legal reasons. The diligence with which patient information is recorded may reflect…

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ABSTRACT NUMBER: NESTAC_12   AUTHORS Ruth V Owen1, Emily R Thompson1, Samuel J Tingle1, Ibrahim K Ibrahim1, L Bates1, Derek M Manas2, Steve A White2, Colin H Wilson1, 2 AFFILIATIONS 1  NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Newcastle University, Newcastle upon Tyne, NE2 4HH 2 Institute of Transplantation, Freeman Hospital,…

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ABSTRACT NUMBER: NESTAC_14   AUTHORS W. Doherty, A. Bowey, P. Sinha, R. Sinclair CORRESPONDING AUTHOR CONTACT EMAIL ku.shn.htun@yewoB.werdnA MAIN ABSTRACT TEXT Background Anaerobic Threshold (AT), quantified through Cardiopulmonary Exercise Testing (CPET), indicates ability to deliver oxygen to metabolizing muscle. AT is used to predict post-operative outcomes across various specialties1; however, its role in Adult Scoliosis…

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ABSTRACT NUMBER: NESTAC_15     AUTHORS Gough, M., Holliman, D. AFFILIATIONS Newcastle University, Newcastle upon Tyne Hospitals Trust CORRESPONDING AUTHOR CONTACT EMAIL ku.ca.lcn@3hguog.m MAIN ABSTRACT TEXT Introduction Patients with intracranial metastases from an unknown primary tumour (CUP) are not always given the same treatment and benefits as those provided for patients with metastases of known…

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NESS & NESTAC Scientific Day 2018

4th May 2018 – Institute of Transplantation, The Freeman Hospital

DM Bourne, JJ French & Acute Pancreatitis Team (JS Leeds, RM Charnley, K Oppong, M Nayar, J Logue, J Scott, S Saikia, S Young & S McMullen) BackgroundSevere acute pancreatitis, as defined by the revised Atlanta classification,1 is caused by an acute inflammatory process affecting the pancreas gland.2 A recent review of acute pancreatitis1 advocated…

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Zakareya Gamie, Anja Krippner-Heidenreich, Craig Gerrand, Kenneth RankinNewcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom BackgroundDespite intensive, multimodal therapy, patients with bone sarcomas have poor 5-year survival, close to 50%. TNF-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in cancer cells, via the extrinsic pathway, after binding to its death receptors: DR4…

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Florence Shekleton, Deena Harji, Ben Griffiths BackgroundMinimally invasive surgical techniques have revolutionised the practice of colorectal surgery. Laparoscopic surgery has led the way followed by the development of robotic-assisted surgery as an alternative approach.  Pelvic exenteration is one of the most technically demanding operations reserved for locally advanced and recurrent pelvic malignancy. AimsTo assess the…

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Charles Johnson, Ross Mclean, Iain Mcallum, Alexander Phillips BackgroundDuodenal perforation is a common surgical emergency. Open repair with omental patch is routine (1), though laparoscopic repair has been shown to be a safe, reliable alternative (2, 3). Non-operative management is generally restricted to patients too unwell for laparotomy or clinically well at initial assessment (4).…

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Nandhra. S, Nesbitt. C, Priona. G, Williams. R, McCaslin. JNorthern Vascular Centre, Freeman Hospital, Newcastle upon Tyne IntroductionComplex endovascular aortic repair is frequently performed using concurrent axillary artery access; this can offer a favourable trajectory for the cannulation of the caudally-orientated visceral vessels. However, associated cerebrovascular complications are reported to be between 2 and 15%.…

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Samuel Tingle, Avinash Sewpaul, Lucy Bates, Rodrigo Figueiredo, Simi Ali, Neil Sheerin, Colin Wilson Introduction Ischaemia reperfusion injury (IRI) causes significant damage to organs from deceased donors. microRNAs are short non-coding RNAs which each cause repression of many target genes. miR-24-3p and miR-145-5p are two microRNAs with potential detrimental roles in IRI. Our group has…

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RJM Morrison 1,2, D Bunn 3, WK Gray 3, PN Baker 4,5, C White 4, A Rangan 4,5,6, KS Rankin 2, MR Reed 1,2,51 – Department of Orthopaedics, Northumbria Healthcare NHS Foundation Trust, UK 2 – Newcastle University, UK 3 – Research & Development, Northumbria Healthcare NHS Foundation Trust, UK 4 – Department of Orthopaedics,…

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Jacob Begbie, Mohammed Fageer IntroductionGallstone related pathology (GD) accounts for a large proportion of general surgery acute admissions, with 3% of acute admissions due to acute cholecystitis (AC). Guidelines from NICE and AUGIS state that AC patients should be offered laparoscopic cholecystectomy (LC) within 7 days of diagnosis (ALC). Despite this, treatment of AC differs…

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Bradish T, Kelly C, Paleri V, Robinson M, O’Hara J BackgroundThe 8th edition of the TNM staging system introduced a new staging model for HPV related oropharyngeal squamous cell carcinoma (OPSCC).  The dataset original study behind this staging system included patients from 7 centres across North America and Europe[1] ObjectivesThis study aimed to assess how…

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Thomas R. Jones (1), Srinivas Annavarapu (2)1 – Newcastle University Medical School, 2 – Royal Victoria Infirmary, Newcastle upon Tyne Paediatric heart transplant (pHTx) is the “gold standard” for children with congenital heart diseases resulting in cardiac failure. However, it is challenging and uncommon and therefore only undertaken in two sites in the UK: The…

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N Newton, AW Phillips, H Jaretzke, A Immanuel, N Hayes, SM Griffin BackgroundFollowing a diagnosis of oesophageal cancer UICC TNM staging guides treatment and informs prognosis. There is recognised variance between clinical staging (cTNM) and post-operative pathological staging ((y)pTNM). T3N3 oesophageal cancers have a 5-year survival of less than 25% in most studies; given the…

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Jones R, Olatunbode D, Dean J, Hall B, Harji D, Davis P, on behalf of the IMPACT investigators IntroductionIn young adults with indeterminate right iliac fossa (RIF) pain, the need for surgery often relates to the likelihood of appendicitis. Ultrasound (US) is widely used in this setting despite a low diagnostic accuracy for appendicitis. We…

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Mr Bertram Marks, Dr FEB May Introduction The incidence of oesophageal adenocarcinoma has increased six-fold over the past 40 years. Despite the increased prevalence, the 5-year mortality is still less than 15% and treatment doesn’t extend much beyond oesophagectomy. Co-activators of Rac1, DOCK2 and ELMO1, were found to be mutated in 17% of oesophageal adenocarcinomas…

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Abdullah K Malik, Steven Masson, Elisa Allen, Murat Akyol, Andrew Bathgate, Mervyn Davies, Ernest Hidalgo, Mark Hudson, James Powell, Agne Zarankaite, Derek M Manas On behalf of the Northern Liver Alliance (NLA) BackgroundThe Northern Liver Alliance (NLA) is a supra-regional allocation system for patients at 3 UK liver transplant centres (Newcastle, Edinburgh and Leeds). Patients…

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JX Lee (1), A Varma (2), P Kane (2)1. Medical School, University of Newcastle2. Department of Neurosurgery, James Cook University Hospital, Middlesbrough BackgroundIn June 2015, National Institute for Health and Care Excellence (NICE) published revised 2WW referral guidelines for general practitioners (GP) for patients with suspected brain and CNS cancer. The comprehensive guidelines include recommendations…

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Espeed Khoshbin, Joseph Battle, Hazel Muse, Kirstie Wallace, George Ditchburn, Gareth Parry, Stephen Clark BackgroundPatient and referring physician choice often means that some lung transplant recipients may reside considerable distances from their transplant centre compared with others. We reviewed a single centre experience to examine the effect of distance from home to the transplant centre…

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M.Koziara, AB. Scrimshire, P.Torres IntroductionEXOGEN therapy is established in the management of fracture delayed/non-unions. It has recently been recommended by NICE for use in trauma. Use of EXOGEN in delayed unions in elective foot and ankle surgery has not been previously reported.  We aim to review the indications and outcomes of EXOGEN therapy in managing…

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Nicole Gull IntroductionThe ALPPS (Associating Liver Partition and Portal vein Ligation for Staged hepatectomy) procedure is a novel surgical approach for the management of primary and secondary liver cancers, first described in the literature in 2012. The aim of this review was to evaluate the effectiveness of ALPPS procedures in our centre and compare our…

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