Impact of social deprivation on short and long term outcomes after acute pancreatitis

ABSTRACT NUMBER: NESTAC MEDAL FOR MEDICAL STUDENTS_6

MAIN ABSTRACT TEXT

Introduction
This study evaluated the impact of social deprivation on short- and long-term outcomes in patients with Acute pancreatitis (AP).

Methods
All AP admissions between 2018-2021 at a high-volume pancreatic centre were analysed. Deprivation (index of multiple deprivation [IMD]) data was sourced from the English indices of deprivation, by postcode. Primary outcome was overall survival. Secondary outcomes included length of hospital stay (LOS) and complications. Cox-proportional hazard analyses were conducted

Results
396 patients were included in the analysis. Patients were grouped into five individual quintiles (IMD 1-2; 3-4; 5-6; 7-8; 9-10). The quintiles were comparable in baseline demographics for gender, past medical history, pre-morbidity scores and laboratory results. However, a higher proportion of patients living in more deprived areas were younger (52.4 in Q1 vs 65.2 in Q5, (P<0.001), smokers (39.1% in Q1 vs 23.7% in Q5, P=0.044) and has ischaemic heart disease (95.0% vs 92.1% in Q5, P<0.001). There was no significance difference in pancreatitis complications, severity, and overall LOS between quintiles. Univariate regression showed lower IMD scores were not associated with ICU admission, as well as worst short and long-term survival outcomes. Multivariate analysis demonstrated significantly poorer survival outcomes with older age, high prothrombin time and need for ventilation support.

Conclusion
Social deprivation does not appear to significantly impact short- and long-term outcomes in patients with AP. Advancing age and need for ICU admission were more likely to determine survival outcomes in AP.