Evaluating Role Radiotherapy in Management of Acinic cell cancers(ACC)–a systematic review of literature

ABSTRACT NUMBER: FEGGETTER MEDAL FOR SENIOR TRAINEES (ST3+)_7

 

AUTHOR
Lubna Sayyed Akber Uzzaman

MAIN ABSTRACT TEXT

Introduction
ACC are low grade cancers with 86.3% arising in parotid and constituting 10% of salivary gland tumors. . Despite having low-grade behaviour, ACCs have a tendency to recur with estimated recurrence rate of around 35%. Surgery is the mainstay of treatment In this review article, we have attempted to review the evidence regarding the role of radiotherapy as an adjuvant treatment in the management of the ACC and its impact on the mortality.

Materials & Methods
A literature search was performed by a professional librarian using MEDLINE and EMBASE data bases for eligible studies from 2000 to February 2020 using the terms acinic cell carcinoma, radiotherapy, salivary gland neoplasm, parotid gland neoplasm . Two authors analysed the list to identify 14 suitable studies which were scaled against the Newcastle Ottawa scale(NOS) on the basis of Selection , comparability and outcome .The resulting data was forwarded to the statisticians and based on strength of evidence,10 studies were selected which were divided into 2 categories . Group1 supporting no improvement in OS with addition of radiotherapy and second group supporting evidence otherwise . Results were synthesized and discussed in accordance Synthesis without meta-analysis(SWIM) guidelines.

Results
1st group including 8 studies with higher overall grading on the NOS concluded that Radiotherapy with surgery lead to worst patient outcomes. Whereas, Group2 with 2 studies which showed significantly overall-low grading on NOS suggested otherwise.

Conclusion
Addition of RT in pts of ACC does not appear to improve survival outcomes.