M.Koziara, AB. Scrimshire, P.Torres IntroductionEXOGEN therapy is established in the management of fracture delayed/non-unions. It has recently been recommended by NICE for use in trauma. Use of EXOGEN in delayed unions in elective foot and ankle surgery has not been previously reported. We aim to review the indications and outcomes of EXOGEN therapy in managing…
Trauma & Orthopaedic
Successful recruitment to a feasibility trial investigating if supplementation for Vitamin D deficiency improves outcomes following total hip or knee replacement: The VASO feasibility Trial – early results. (FEGGETTER MEDAL WINNER)
RJM Morrison 1,2, D Bunn 3, WK Gray 3, PN Baker 4,5, C White 4, A Rangan 4,5,6, KS Rankin 2, MR Reed 1,2,51 – Department of Orthopaedics, Northumbria Healthcare NHS Foundation Trust, UK 2 – Newcastle University, UK 3 – Research & Development, Northumbria Healthcare NHS Foundation Trust, UK 4 – Department of Orthopaedics,…
Preclinical testing of TRAIL therapeutics for sarcoma
Zakareya Gamie, Anja Krippner-Heidenreich, Craig Gerrand, Kenneth RankinNewcastle University, Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom BackgroundDespite intensive, multimodal therapy, patients with bone sarcomas have poor 5-year survival, close to 50%. TNF-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in cancer cells, via the extrinsic pathway, after binding to its death receptors: DR4…